Gather all ingredients on a clean surface.

In a large bowl, combine ground turkey, breadcrumbs, egg, garlic powder, onion powder, salt, and pepper. Mix gently until just combined.

Divide the mixture into four equal portions and shape into patties about one inch thick.

Preheat grill to medium-high heat (375°F). Oil the grates lightly.

Grill patties for 5-6 minutes per side until they reach an internal temperature of 165°F.

Toast burger buns on the grill for about one minute.

Assemble burgers with desired toppings and sauces.